Inflammation, HIF-1, and the Epigenetics That Follows

• Main Authors: Claudio Brigati (Author), Barbara Banelli (Author), Angela di Vinci (Author), Ida Casciano (Author), Giorgio Allemanni (Author), Alessandra Forlani (Author), Luana Borzì (Author), Massimo Romani (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We summarize recent findings linking inflammatory hypoxia to chromatin modifications, in particular to repressive histone signatures. We focus on the role of Hypoxia-Induced Factor-1 in promoting the activity of specific histone demethylases thus deeply modifying chromatin configuration. The consequ...