A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties

• Asıl Yazarlar: Rezeda A. Ishkaeva (Yazar), Diana V. Salakhieva (Yazar), Ruslan Garifullin (Yazar), Raghad Alshadidi (Yazar), Alexander V. Laikov (Yazar), Abdulla A. Yergeshov (Yazar), Marat I. Kamalov (Yazar), Timur I. Abdullin (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to increase reducing activity of both stereoisomeric peptides i...