A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties

• Hauptverfasser: Rezeda A. Ishkaeva (Verfasst von), Diana V. Salakhieva (Verfasst von), Ruslan Garifullin (Verfasst von), Raghad Alshadidi (Verfasst von), Alexander V. Laikov (Verfasst von), Abdulla A. Yergeshov (Verfasst von), Marat I. Kamalov (Verfasst von), Timur I. Abdullin (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2023-01-01T00:00:00Z.
• Schlagworte: article
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We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to increase reducing activity of both stereoisomeric peptides i...