A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties

• Main Authors: Rezeda A. Ishkaeva (Author), Diana V. Salakhieva (Author), Ruslan Garifullin (Author), Raghad Alshadidi (Author), Alexander V. Laikov (Author), Abdulla A. Yergeshov (Author), Marat I. Kamalov (Author), Timur I. Abdullin (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetrating and cytoprotective motif. TPP moiety was found to increase reducing activity of both stereoisomeric peptides i...