Ppp4r3a deficiency leads to depression-like behaviors in mice by modulating the synthesis of synaptic proteins

• Main Authors: Fei Gao (Author), Ai Liu (Author), Xing Qi (Author), Meitian Wang (Author), Xiao Chen (Author), Shijun Wei (Author), Shang Gao (Author), Yueqing Sun (Author), Ping Sun (Author), Xi Li (Author), Wenjie Sun (Author), Jiangxia Li (Author), Qiji Liu (Author)
• Format: Book
• Published: The Company of Biologists, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic stress is one of the main risk factors for the onset of major depressive disorder. Chronic unpredictable mild stress results in reduced expression of synaptic proteins and depression-like behaviors in rodent models. However, the upstream molecule that senses the demand for synaptic proteins...