Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

• Main Authors: Scott M. Irwin (Author), Emily Driver (Author), Edward Lyon (Author), Christopher Schrupp (Author), Gavin Ryan (Author), Mercedes Gonzalez-Juarrero (Author), Randall J. Basaraba (Author), Eric L. Nuermberger (Author), Anne J. Lenaerts (Author)
• Format: Book
• Published: The Company of Biologists, 2015-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in...