Inactivation of a New Potassium Channel Increases Rifampicin Resistance and Induces Collateral Sensitivity to Hydrophilic Antibiotics in <i>Mycobacterium smegmatis</i>

• Main Authors: Thi Thuy Do (Author), Jerónimo Rodríguez-Beltran (Author), Esmeralda Cebrián-Sastre (Author), Alexandro Rodríguez-Rojas (Author), Alfredo Castañeda-García (Author), Jesús Blázquez (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. Rifampicin resistance in mycobacteria is mainly caused by mutations in the <i>rpoB</i> gene; however, some rifampicin-resistan...