Oxalate regulates crystal-cell adhesion and macrophage metabolism via JPT2/PI3K/AKT signaling to promote the progression of kidney stones

• Main Authors: Qianlin Song (Author), Chao Song (Author), Xin Chen (Author), Yunhe Xiong (Author), Ziqi He (Author), Xiaozhe Su (Author), Jiawei Zhou (Author), Hu Ke (Author), Caitao Dong (Author), Wenbiao Liao (Author), Sixing Yang (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxalate is an organic dicarboxylic acid that is a common component of plant foods. The kidneys are essential organs for oxalate excretion, but excessive oxalates may induce kidney stones. Jupiter microtubule associated homolog 2 (JPT2) is a critical molecule in Ca2+ mobilization, and its intrinsic m...