Genomewide association study identifies a novel variant associated with tacrolimus trough concentration in Chinese renal transplant recipients

• Main Authors: Siyao Yang (Author), Haixia Jiang (Author), Chengcheng Li (Author), Huijie Lu (Author), Chuanjiang Li (Author), Demei Ye (Author), Huana Qi (Author), Wenbin Xu (Author), Xiaojie Bao (Author), Nicola Maseko (Author), Siqi Zhang (Author), Ruifan Shao (Author), Liang Li (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability in pharmacokinetics (PKs). Genetic and clinical factors play important roles in TAC PKs. We enrolled a total of 251 Chinese renal transplant recipients and c...