Ovarian cancer modulates the immunosuppressive function of CD11b+Gr1+ myeloid cells via glutamine metabolism

• Main Authors: Mary P. Udumula (Author), Sharif Sakr (Author), Sajad Dar (Author), Ayesha B. Alvero (Author), Rouba Ali-Fehmi (Author), Eman Abdulfatah (Author), Jing Li (Author), Jun Jiang (Author), Amy Tang (Author), Thomas Buekers (Author), Robert Morris (Author), Adnan Munkarah (Author), Shailendra Giri (Author), Ramandeep Rattan (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Immature CD11b + Gr1+ myeloid cells that acquire immunosuppressive capability, also known as myeloid-derived suppressor cells (MDSCs), are a heterogeneous population of cells that regulate immune responses. Our study's objective was to elucidate the role of ovarian cancer microenviro...