Synthesis, Computational Study, and In Vitro α-Glucosidase Inhibitory Action of 1,3,4-Thiadiazole Derivatives of 3-Aminopyridin-2(1<i>H</i>)-ones

• Main Authors: Zarina Shulgau (Author), Irina V. Palamarchuk (Author), Shynggys Sergazy (Author), Assel Urazbayeva (Author), Yerlan Ramankulov (Author), Ivan V. Kulakov (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This article reports on the synthesis of nine promising new 1,3,4-thiadiazole derivatives based on 3-aminopyridones, containing various acidic linkers. The synthesis was carried out by cyclizing the corresponding thiohydrazides <b>4a</b>-<b>c</b> and anhydrides of glutaric, m...