Nicotine- and Tar-free Cigarette Smoke Extract Induces Cell Injury via Intracellular Ca2+-Dependent Subtype-Specific Protein Kinase C Activation

• 主要な著者: Yosuke Mai (著者), Tsunehito Higashi (著者), Koji Terada (著者), Chizuru Hatate (著者), Prabha Nepal (著者), Mika Horiguchi (著者), Takuya Harada (著者), Soichi Miwa (著者), Takahiro Horinouchi (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2012-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Nicotine- and tar-free cigarette smoke extract (CSE) is reported to induce cell damage via activation of protein kinase C (PKC) and NADPH oxidase (NOX) in rat C6 glioma cells. Here we determined PKC isozyme(s) activated by CSE and their activation mechanism. In C6 glioma cells, mRNAs for PKCα, PKCδ,...