Nicotine- and Tar-free Cigarette Smoke Extract Induces Cell Injury via Intracellular Ca2+-Dependent Subtype-Specific Protein Kinase C Activation

• Main Authors: Yosuke Mai (Author), Tsunehito Higashi (Author), Koji Terada (Author), Chizuru Hatate (Author), Prabha Nepal (Author), Mika Horiguchi (Author), Takuya Harada (Author), Soichi Miwa (Author), Takahiro Horinouchi (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nicotine- and tar-free cigarette smoke extract (CSE) is reported to induce cell damage via activation of protein kinase C (PKC) and NADPH oxidase (NOX) in rat C6 glioma cells. Here we determined PKC isozyme(s) activated by CSE and their activation mechanism. In C6 glioma cells, mRNAs for PKCα, PKCδ,...