Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

• Main Authors: Shion A. Lim (Author), Josef A. Gramespacher (Author), Katarina Pance (Author), Nicholas J. Rettko (Author), Paige Solomon (Author), Jing Jin (Author), Irene Lui (Author), Susanna K. Elledge (Author), Jia Liu (Author), Colton J. Bracken (Author), Graham Simmons (Author), Xin X. Zhou (Author), Kevin K. Leung (Author), James A. Wells (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...