Quantifying Drug‐Induced Bone Marrow Toxicity Using a Novel Haematopoiesis Systems Pharmacology Model

• Main Authors: Chiara Fornari (Author), Lenka Oplustil O'Connor (Author), Carmen Pin (Author), Aaron Smith (Author), James W.T. Yates (Author), S.Y. Amy Cheung (Author), Duncan I. Jodrell (Author), Jerome T. Mettetal (Author), Teresa A. Collins (Author)
• Format: Book
• Published: Wiley, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Haematological toxicity associated with cancer therapeutics is monitored by changes in blood cell count, and their primary effect is on proliferative progenitors in the bone marrow. Using observations in rat bone marrow and blood, we characterize a mathematical model that comprises cell proliferatio...