ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms

• Main Authors: Sara Rocha (Author), Jorge Vieira (Author), Noé Vázquez (Author), Hugo López-Fernández (Author), Florentino Fdez-Riverola (Author), Miguel Reboiro-Jato (Author), André D. Sousa (Author), Cristina P. Vieira (Author)
• Format: Book
• Published: BMC, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger...