ATXN1 N-terminal region explains the binding differences of wild-type and expanded forms
Abstract Background Wild-type (wt) polyglutamine (polyQ) regions are implicated in stabilization of protein-protein interactions (PPI). Pathological polyQ expansion, such as that in human Ataxin-1 (ATXN1), that causes spinocerebellar ataxia type 1 (SCA1), results in abnormal PPI. For ATXN1 a larger...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
BMC,
2019-10-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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