Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening

• Main Authors: Albertus Eka Yudistira Sarwono (Author), Shinya Mitsuhashi (Author), Mohammad Hazzaz Bin Kabir (Author), Kengo Shigetomi (Author), Tadashi Okada (Author), Fumina Ohsaka (Author), Satoko Otsuguro (Author), Katsumi Maenaka (Author), Makoto Igarashi (Author), Kentaro Kato (Author), Makoto Ubukata (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inosine 5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppression, antiviral, and antimicrobial therapy. In th...