L-cysteine methyl ester overcomes the deleterious effects of morphine on ventilatory parameters and arterial blood-gas chemistry in unanesthetized rats

• Main Authors: Paulina M. Getsy (Author), Santhosh M. Baby (Author), Walter J. May (Author), James N. Bates (Author), Christopher R. Ellis (Author), Michael G. Feasel (Author), Christopher G. Wilson (Author), Tristan H. J. Lewis (Author), Benjamin Gaston (Author), Yee-Hsee Hsieh (Author), Stephen J. Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We are developing a series of thiolesters that produce an immediate and sustained reversal of the deleterious effects of opioids, such as morphine and fentanyl, on ventilation without diminishing the antinociceptive effects of these opioids. We report here the effects of systemic injections of L-cys...