Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway

• Main Authors: Xiaonan Kang (Author), Dan Wang (Author), Lu Zhang (Author), Teng Huang (Author), Siyue Liu (Author), Xiaohui Feng (Author), Yaoyao Guo (Author), Ziyin Zhang (Author), Zhongjing Wang (Author), Huihui Ren (Author), Gang Yuan (Author)
• Format: Book
• Published: BMC, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background  Type 2 diabetes (T2D) is an independent risk factor for Alzheimer's disease (AD). Exendin-4 (Ex-4), a widely used glucagon-like peptide-1 receptor agonist drug in the treatment of T2D, has been demonstrated the therapeutic effects on diabetic encephalopathy (DE). Especially...