Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

• Главные авторы: Guihua Sun (Автор), Spencer Yele Yeh (Автор), Christine Wan-Yin Yuan (Автор), Margaret Jean-Yih Chiu (Автор), Bryan Shing Hei Yung (Автор), Yun Yen (Автор)
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• Опубликовано: Elsevier, 2015-01-01T00:00:00Z.
• Предметы: article
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Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...