Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

• Main Authors: Guihua Sun (Author), Spencer Yele Yeh (Author), Christine Wan-Yin Yuan (Author), Margaret Jean-Yih Chiu (Author), Bryan Shing Hei Yung (Author), Yun Yen (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...