Integrated metabolomics analysis reveals mechanistic insights into variability in blood pressure response to thiazide diuretics and beta blockers

• Main Authors: Mai Mehanna (Author), Caitrin W. McDonough (Author), Steven M. Smith (Author), Yan Gong (Author), John G. Gums (Author), Arlene B. Chapman (Author), Julie A. Johnson (Author), Rhonda M. Cooper‐DeHoff (Author)
• Format: Book
• Published: Wiley, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hypertensive patients with a higher proportion of genetic West African ancestry (%GWAA) have better blood pressure (BP) response to thiazide diuretics (TDs) and worse response to β‐blockers (BBs) than those with lower %GWAA, associated with their lower plasma renin activity (PRA). TDs and B...