Population pharmacokinetic model for once‐daily intravenous busulfan in pediatric subjects describing time‐associated clearance

• Main Authors: Rachael Lawson (Author), Christine E. Staatz (Author), Christopher J. Fraser (Author), Shanti Ramachandran (Author), Lochie Teague (Author), Richard Mitchell (Author), Tracey O'Brien (Author), Stefanie Hennig (Author)
• Format: Knjiga
• Izdano: Wiley, 2022-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract This study aimed to characterize the population pharmacokinetics (PK) of busulfan focusing on how busulfan clearance (CL) changes over time during once‐daily administration and assess different methods for measuring busulfan exposure and the ability to achieve target cumulative exposure und...