Theranostic mesoporous platinum nanoplatform delivers halofuginone to remodel extracellular matrix of breast cancer without systematic toxicity

• Main Authors: Jie Zhang (Author), Ziqing Xu (Author), Yang Li (Author), Yongzhi Hu (Author), Jiajia Tang (Author), Jiaqi Xu (Author), Yafei Luo (Author), Feiyun Wu (Author), Xiaolian Sun (Author), Yuxia Tang (Author), Shouju Wang (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The enriched collagens in the extracellular matrix (ECM) of breast cancer substantially impede drug delivery. Halofuginone (HF), a potent antifibrotic agent, was effective to deplete the collagens and remodel the ECM by inhibiting the TGFβ pathway. However, the application of HF was hindere...