Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation.

• Main Authors: Karine Thivierge (Author), Sophie Cotton (Author), Deborah A Schaefer (Author), Michael W Riggs (Author), Joyce To (Author), Maria E Lund (Author), Mark W Robinson (Author), John P Dalton (Author), Sheila M Donnelly (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Host defence peptides (HDPs) are expressed throughout the animal and plant kingdoms. They have multifunctional roles in the defence against infectious agents of mammals, possessing both bactericidal and immune-modulatory activities. We have identified a novel family of molecules secreted by helminth...