Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes

• Main Authors: Sa Feng (Author), Linyan Liu (Author), Yuelin Cheng (Author), Mengmeng Zhou (Author), Haoqiang Zhu (Author), Xinyan Zhao (Author), Ziyu Chen (Author), Shunli Kan (Author), Xuanhao Fu (Author), Wei Hu (Author), Rusen Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectiveThe limited ability to regenerate axons after spinal cord injury (SCI) is influenced by factors such as astrocyte activation, reactive proliferation, and glial scar formation. The TGF-β/Smad (transforming growth factor-β/mothers against decapentaplegic homolog) pathway, associated with astr...