Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase.

• Main Authors: Laura-Isobel McCall (Author), Amale El Aroussi (Author), Jun Yong Choi (Author), Debora F Vieira (Author), Geraldine De Muylder (Author), Jonathan B Johnston (Author), Steven Chen (Author), Danielle Kellar (Author), Jair L Siqueira-Neto (Author), William R Roush (Author), Larissa M Podust (Author), James H McKerrow (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leishmania protozoan parasites (Trypanosomatidae family) are the causative agents of cutaneous, mucocutaneous and visceral leishmaniasis worldwide. While these diseases are associated with significant morbidity and mortality, there are few adequate treatments available. Sterol 14alpha-demethylase (C...