Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3

• Hoofdauteurs: Katherine J. Robinson (Auteur), Madelaine C. Tym (Auteur), Alison Hogan (Auteur), Maxinne Watchon (Auteur), Kristy C. Yuan (Auteur), Stuart K. Plenderleith (Auteur), Emily K. Don (Auteur), Angela S. Laird (Auteur)
• Formaat: Boek
• Gepubliceerd in: The Company of Biologists, 2021-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Spinocerebellar ataxia 3 (SCA3, also known as Machado-Joseph disease) is a neurodegenerative disease caused by inheritance of a CAG repeat expansion within the ATXN3 gene, resulting in polyglutamine (polyQ) repeat expansion within the ataxin-3 protein. In this study, we have identified protein aggre...