Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

• প্রধান লেখক: Alberto Malerba (লেখক), Jagjeet K Kang (লেখক), Graham McClorey (লেখক), Amer F Saleh (লেখক), Linda Popplewell (লেখক), Michael J Gait (লেখক), Matthew JA Wood (লেখক), George Dickson (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2012-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The knockdown of myostatin, a negative regulator of skeletal muscle mass may have important implications in disease conditions accompanied by muscle mass loss like cancer, HIV/AIDS, sarcopenia, muscle atrophy, and Duchenne muscular dystrophy (DMD). In DMD patients, where major muscle loss has occurr...