Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones

• Main Authors: Priscila López-Rojas (Author), Ángel Amesty (Author), Miguel Guerra-Rodríguez (Author), Yeray Brito-Casillas (Author), Borja Guerra (Author), Leandro Fernández-Pérez (Author), Ana Estévez-Braun (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on molecular docking studies on the ERα, a series of lignan derivatives (<b>3</b>-<b>16</b>) were designed and semisynthesized from the natural dibenzylbutyrolactones bursehernin (<b>1</b>) and matairesinol dimethyl ether (<b>2</b>). To examine t...