Design, Semisynthesis, and Estrogenic Activity of Lignan Derivatives from Natural Dibenzylbutyrolactones

• Prif Awduron: Priscila López-Rojas (Awdur), Ángel Amesty (Awdur), Miguel Guerra-Rodríguez (Awdur), Yeray Brito-Casillas (Awdur), Borja Guerra (Awdur), Leandro Fernández-Pérez (Awdur), Ana Estévez-Braun (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2022-05-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Based on molecular docking studies on the ERα, a series of lignan derivatives (<b>3</b>-<b>16</b>) were designed and semisynthesized from the natural dibenzylbutyrolactones bursehernin (<b>1</b>) and matairesinol dimethyl ether (<b>2</b>). To examine t...