Beneficial effect of prolonged heme oxygenase 1 activation in a rat model of chronic heart failure

• Main Authors: Massimo Collino (Author), Alessandro Pini (Author), Niccolò Mugelli (Author), Rosanna Mastroianni (Author), Daniele Bani (Author), Roberto Fantozzi (Author), Laura Papucci (Author), Marilena Fazi (Author), Emanuela Masini (Author)
• Format: Book
• Published: The Company of Biologists, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY We and others have previously demonstrated that heme oxygenase 1 (HO-1) induction by acute hemin administration exerts cardioprotective effects. Here, we developed a rat model of heart failure to investigate whether a long-term induction of HO-1 by chronic hemin administration exerted protec...