Tumor Microenvironment Responsive Nanomicelle with Folic Acid Modification Co-Delivery of Doxorubicin/Shikonin for Triple Negative Breast Cancer Treatment

• Главные авторы: Wu Zhong (Автор), Zhehao Shen (Автор), Menglan Wang (Автор), Hongyi Wang (Автор), Yuting Sun (Автор), Xiaojun Tao (Автор), Defu Hou (Автор)
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• Опубликовано: MDPI AG, 2023-03-01T00:00:00Z.
• Предметы: article
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Triple negative breast cancer (TNBC), which has poor prognosis, easily develops drug resistance and metastasizes. In general, those TNBC characteristics are related to a high activation of the epithelial-mesenchymal transition (EMT) pathway, which is inhibited by shikonin (SKN). Therefore, the syner...