Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines

• Main Authors: Elizabeth Curtiss (Author), Youde Jiang (Author), Li Liu (Author), Claire Hawthorne (Author), Jessica Zhang (Author), Jena J. Steinle (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously reported that Epac1 reduced inflammatory cytokines, which is protective to the diabetic retina. We have also published that impaired insulin signaling occurs in the diabetic retina. A reduction in interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNFα) by Epac1 could pot...