Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1

• Main Authors: Lang Deng (Author), Weixi Xie (Author), Miao Lin (Author), Dayan Xiong (Author), Lei Huang (Author), Xiaohua Zhang (Author), Rui Qian (Author), Xiaoting Huang (Author), Siyuan Tang (Author), Wei Liu (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there is a lack of effective drug treatment. As the major cells of sepsis-induced ALI, macrophages polarize toward the proinflammatory M1 phenotype and secrete multiple inflammatory cytokines to accele...