Taraxerone inhibits M1 polarization and alleviates sepsis-induced acute lung injury by activating SIRT1

• Автори: Lang Deng (Автор), Weixi Xie (Автор), Miao Lin (Автор), Dayan Xiong (Автор), Lei Huang (Автор), Xiaohua Zhang (Автор), Rui Qian (Автор), Xiaoting Huang (Автор), Siyuan Tang (Автор), Wei Liu (Автор)
• Формат: Книга
• Опубліковано: BMC, 2024-11-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there is a lack of effective drug treatment. As the major cells of sepsis-induced ALI, macrophages polarize toward the proinflammatory M1 phenotype and secrete multiple inflammatory cytokines to accele...