Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1

• Main Authors: Nishant Mohan (Author), Atul Agrawal (Author), Yi Shen (Author), Katie L. Winarski (Author), Yukinori Endo (Author), Milos Dokmanovic (Author), Deborah Schmiel (Author), Jiwen Zheng (Author), David S. Rotstein (Author), Lorraine C. Pelosof (Author), Wen Jin Wu (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We generated two IgG1-like bispecific antibodies (BsAbs) with different molecular formats, symmetrical DVD-Ig and asymmetrical knob-in-hole (KIH), targeting the same antigens, EGFR and PD-L1 (designated as anti-EGFR/PD-L1). We performed the physiochemical and biological characterization of these two...