Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium

• Main Authors: Karla Consort Ribeiro (Author), Roberto Perez Campelo (Author), Daniela del Rosário Flores Rodrigues (Author), Elisabete C. Mattos (Author), Izaira Trincani Brandão (Author), Célio Lopes da Silva (Author), Eliete Bouskela (Author), Camila Guerra Martinez (Author), Eleonora Kurtenbach (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Autoantibodies against the M2 subtype of muscarinic acetylcholine receptors with functional activities have been found in the sera of patients with dilated cardiomyopathy (DCM), and the second extracellular loop has been established as the predominant epitope. However, it has been shown that the thi...