ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway

• Main Authors: Yu-wei Yang (Author), Xin Meng (Author), Yuan-yuan Meng (Author), Hai-kang Tang (Author), Ming-hui Cheng (Author), Zi-qi Zhang (Author), Wen-qing Xu (Author), Wei Long (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the relentless renewal ability of intestinal crypt-base stem cells, small intestine in the gastrointestinal (GI) tract is more vulnerable to radiation-induced disruption. Through promoting epithelial integrity and reducing intracellular reactive oxygen species (ROS) levels, hypoxia-inducible f...