Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies

• Main Authors: Amita Datta-Mannan (Author), Selina Estwick (Author), Chen Zhou (Author), Hiuwan Choi (Author), Nicole E. Douglass (Author), Derrick R. Witcher (Author), Jirong Lu (Author), Catherine Beidler (Author), Rohn Millican (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Many therapeutic monoclonal antibodies (mAbs) were initially developed for intravenous (IV) administration. As a means to improve mAb drug-ability and the patient experience, subcutaneous (SC) administration is an increasingly important delivery route for mAbs. Unlike IV administration, bioavailabil...