Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

• Główni autorzy: Thomas Sécher (Autor), Elsa Bodier-Montagutelli (Autor), Christelle Parent (Autor), Laura Bouvart (Autor), Mélanie Cortes (Autor), Marion Ferreira (Autor), Ronan MacLoughlin (Autor), Guy Ilango (Autor), Otmar Schmid (Autor), Renaud Respaud (Autor), Nathalie Heuzé-Vourc'h (Autor)
• Format: Książka
• Wydane: MDPI AG, 2022-03-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Background: Immunogenicity refers to the inherent ability of a molecule to stimulate an immune response. Aggregates are one of the major risk factors for the undesired immunogenicity of therapeutic antibodies (Ab) and may ultimately result in immune-mediated adverse effects. For Ab delivered by inha...