Aggregates Associated with Instability of Antibodies during Aerosolization Induce Adverse Immunological Effects

• 主要な著者: Thomas Sécher (著者), Elsa Bodier-Montagutelli (著者), Christelle Parent (著者), Laura Bouvart (著者), Mélanie Cortes (著者), Marion Ferreira (著者), Ronan MacLoughlin (著者), Guy Ilango (著者), Otmar Schmid (著者), Renaud Respaud (著者), Nathalie Heuzé-Vourc'h (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: Immunogenicity refers to the inherent ability of a molecule to stimulate an immune response. Aggregates are one of the major risk factors for the undesired immunogenicity of therapeutic antibodies (Ab) and may ultimately result in immune-mediated adverse effects. For Ab delivered by inha...