Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation

• 主要な著者: Brandon W. Lewis (著者), Maria L. Ford (著者), Aiman Q. Khan (著者), Joshua Walum (著者), Rodney D. Britt (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Type 2-high severe asthma is described as a distinct endotype with Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. While the inflammatory milieu is similar to mild asthma, patients with type 2-high severe asthma likely have underly...