Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi.

• Main Authors: Leroy Versteeg (Author), Rakesh Adhikari (Author), Cristina Poveda (Author), Maria Jose Villar-Mondragon (Author), Kathryn M Jones (Author), Peter J Hotez (Author), Maria Elena Bottazzi (Author), Edwin Tijhaar (Author), Jeroen Pollet (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tc24-C4, a modified recombinant flagellar calcium-binding protein of Trypanosoma cruzi, is under development as a therapeutic subunit vaccine candidate to prevent or delay progression of chronic Chagasic cardiomyopathy. When combined with Toll-like receptor agonists, Tc24-C4 immunization reduces par...