Novel 2-substituted-benzimidazole-6-sulfonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IX and XII and molecular docking studies

• Main Authors: Ciro Milite (Author), Giorgio Amendola (Author), Alessio Nocentini (Author), Silvia Bua (Author), Alessandra Cipriano (Author), Elisabetta Barresi (Author), Alessandra Feoli (Author), Ettore Novellino (Author), Federico Da Settimo (Author), Claudiu T. Supuran (Author), Sabrina Castellano (Author), Sandro Cosconati (Author), Sabrina Taliani (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of Carbonic Anhydrases (CAs) has been clinically exploited for many decades for a variety of therapeutic applications. Within a research project aimed at developing novel classes of CA inhibitors (CAIs) with a proper selectivity for certain isoforms, a series of derivatives featuring the...