Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia

• Main Authors: Pauline Thémans (Author), Pierre Marquet (Author), Joseph J. Winkin (Author), Flora T. Musuamba (Author)
• פורמט: ספר
• יצא לאור: Adis, Springer Healthcare, 2019-05-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Objective The objective of this study was to develop a physiologically based pharmacokinetic model for meropenem using a retrograde approach, which could serve as a basis for prediction of the systemic and infection-site drug exposures in different populations and indications. We intended t...