Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer's disease

In this work, we designed, synthesised and biologically investigated a novel series of 14 N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer's disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylh...

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Main Authors: Maja Przybyłowska (Author), Krystyna Dzierzbicka (Author), Szymon Kowalski (Author), Sebastian Demkowicz (Author), Mateusz Daśko (Author), Iwona Inkielewicz-Stepniak (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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