Effects of 5-Fluorouracil on the Expression of Epigenetic Enzymes and Promoter Methylation of Selected Genes in Monolayer and Spheroid Cultures of Colorectal Cancer Cells

• Main Authors: Maryam Niknam (Author), Masoumeh Varedi (Author), Mozhdeh Zamani (Author), Pooneh Mokarram (Author), Fakhraddin Naghibalhossaini (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Emerging evidence suggests that epigenetic mechanisms contribute to 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). However, there is limited research on the direct impact of 5-FU on epigenetic alterations in CRC. This study aimed to investigate how 5-FU treatment affects th...