Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF^V600E: Design, Synthesis, and Antiproliferative Activity

• Main Authors: Lamya H. Al-Wahaibi (Author), Mohamed Hisham (Author), Hesham A. Abou-Zied (Author), Heba A. Hassan (Author), Bahaa G. M. Youssif (Author), Stefan Bräse (Author), Alaa M. Hayallah (Author), Mohamed Abdel-Aziz (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAF^V600E. These hybrid compounds were tested in vitro against four different cancer cell lines. Compounds <b...