DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

• Main Authors: Yuanyuan Wang (Author), Bin Wei (Author), Danping Wang (Author), Jingjing Wu (Author), Jianhua Gao (Author), Haiqing Zhong (Author), Yang Sun (Author), Qiang Xu (Author), Wen Liu (Author), Yanhong Gu (Author), Wenjie Guo (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastrointestinal mucositis is one of the most debilitating side effects of the chemotherapeutic agent irinotecan (CPT-11). Andrographolide, a natural bicyclic diterpenoid lactone, has been reported to possess anti-colitis activity. In this study, andrographolide treatment was found to significantly...