Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects

• Main Authors: Tuija Väänänen (Author), Lauri Lehtimäki (Author), Katriina Vuolteenaho (Author), Mari Hämäläinen (Author), Panu Oksa (Author), Tuula Vierikko (Author), Ritva Järvenpää (Author), Jukka Uitti (Author), Hannu Kankaanranta (Author), Eeva Moilanen (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis. Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen pro...