Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2'-<i>O</i>-methylation of ribosomal RNAs (rRNAs), a modification essential for acc...

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Main Authors: Yun Shi (Author), Ibrahim M. El-Deeb (Author), Veronika Masic (Author), Lauren Hartley-Tassell (Author), Andrea Maggioni (Author), Mark von Itzstein (Author), Thomas Ve (Author)
Format: Book
Published: MDPI AG, 2021-12-01T00:00:00Z.
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