Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin
Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2'-<i>O</i>-methylation of ribosomal RNAs (rRNAs), a modification essential for acc...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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MDPI AG,
2021-12-01T00:00:00Z.
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